Racism, stereotyping, and discrimination present a potentially considerable hindrance in the lives of urban minority youth. These instances affect both the individual and the larger society by introducing the possibility of maladaptive coping responses, including antisocial attitudes and behaviors. The present investigation explored the relations between the subjective experiences of racial profiling (i.e., perceived negative youth experiences, NYEs) and negative outcomes such as substance use and fighting behavior in a sample of African American urban youth. The goal was not only to uncover these relationships, but also to identify useful buffers between perceived NYEs and negative outcomes. As expected, results demonstrated a direct relation between NYEs and antisocial outcomes, with males reporting more NYEs than females. An expected finding emerged regarding participation in extra-curricular activities for males. When males reported high NYEs coupled with participation in extra-curricular activities, they also reported a lower incidence of marijuana use. Unexpectedly, however, familial support appeared to increase the relation between NYEs and fighting behavior in this sample. Also unexpectedly, females with higher ego-esteem demonstrated more fighting behavior in response to NYEs than females with lower ego-esteem. Furthermore, longitudinal results supported cross-sectional findings regarding age effects of substance use, fighting behavior, and familial support. Limitations and future directions are also discussed