The present study examined the relationships between anxiety, cognitive functioning, weak central coherence, and social skills in a group of 102 children diagnosed with an Autism Spectrum Disorder (ASD; Autistic disorder, Asperger's disorder, and PDD-NOS). The results indicated that children diagnosed with Asperger's disorder had significantly higher cognitive functioning and Block Design scores (i.e., weaker central coherence) compared to those diagnosed with autism or PDD-NOS. Regression analyses results showed that anxiety and cognitive functioning moderated the association between weak central coherence and social skills. For children with low cognitive functioning and high anxiety, weak central coherence was associated with poorer social skills than those with low cognitive functioning, high anxiety, and strong central coherence. For children with high cognitive functioning and high anxiety, weak central coherence was associated with better social skills than those with high cognitive functioning and strong central coherence. Implications of these findings are discussed.