I provide a contribution to post-colonial studies with my unique take on the colonization of México, where systemic rape has arisen as a weapon for societal destruction. Using academic literature and history, I illustrate the negative effects of Spanish colonialism by rape. The rape that occurred in the Spanish conquest of Latin America increased social stratification in the colonial era, and aided in the cultural genocide of indigenous peoples via forced assimilation and the adoption of mestizaje as a cultural identity in the 20th century. To examine this hypothesis, the paper focuses on two time periods. The first time period, from the conquest through colonial New Spain, is one in which being a mestizo meant a lower position in society than the Europeans. The second time period, mid-20th century México, demonstrated a shift in perspective, as the Mexican government purposely elevated the value of mestizaje. This served to create a unified national identity, but also perpetuated a cultural genocide of indigenous peoples through assimilation. This unique manner of colonization clearly has affected México, in these two time periods as well as beyond. My research provides a new perspective for the analysis of Mexican socio-political culture. Linking periods of history in which mestizo identity had an impact allows me to tie the events back to the method of Mexican colonization, with sexual violence that destabilized civil society. In addition to a new analytical lens for studies of México, this work is applicable to contemporary conflict.