Tumors vary greatly in their characteristics and underlying mechanisms. Drosophila provides an excellent model for studying tumor similarity and mechanisms due to its well- understood background and relatively simple genome size and gene-gene interactions. In this study, we downloaded and re-processed over 500 tumor samples from the fly model and found that tumor initiation is not always associated with high proliferation and evading death. By utilizing bioinformatic methods, we identified that under excellent control of Wnt and JNK, cells may not need to show these characteristics to initiate tumors. These findings provide a new perspective on the mechanisms underlying tumor initiation in Drosophila.