Malaria determinants and prevention-centered outcomes across data and literature of vulnerable population
Malaria highest burden falls on high risk groups due to their unique characteristics, low or absent immunity to the infections, and tendency to manifest the sever form of the disease with developing serious complications. In this proposal, three specific aims will be addressed focusing on malaria high risk groups of pregnant women, children under five years of age, and travelers to endemic areas. Two aims will be in the context of the Democratic Republic of the Congo (DRC) utilizing baseline and end line data collected from three sampling areas for evaluating the impact of a largescale health system strengthening project. Specific aim 1) To measure the impact of this project on intermittent preventive treatment in pregnancy with Sulfadoxine-Pyrimethamine (IPTp-SP) uptake at antenatal care (ANC) visits in the DRC. Specific aim 2) To Examine the determinants of malaria infection among children under five years of age in the DRC. To accomplish the third aim, the scientific evidence-based articles across the published and grey literatures will be utilized. Specific aim 3) To assess the occurrence of mefloquine (MQ) related neuropsychiatric adverse events (NPAE) when prescribed as a malaria chemoprophylaxis for travelers to endemic regions. An in-depth analyses will be applied to achieve the stated aims. The findings might serve as an input for decision makers for shaping future malaria and relevant health system policies, with allocating resources and targeted interventions to where they are needed the most by malaria high risk population.